Search results for "INTRINSIC AEROBIC CAPACITY"
showing 2 items of 2 documents
Physical activity in adulthood: genes and mortality.
2015
AbstractObservational studies report a strong inverse relationship between leisure-time physical activity and all-cause mortality. Despite suggestive evidence from population-based associations, scientists have not been able to show a beneficial effect of physical activity on the risk of death in controlled intervention studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence physical activity levels, cardiorespiratory fitness and risk of de…
Mitochondrial function and sirtuin expression in hippocampus of young and old high- and low-capacity runner rats
2016
Introduction: Exercise and aerobic capacity are associated with improved learning in animals and humans. The hippocampus is a brain structure involved in learning and memory. High rates of neurogenesis have been shown to take place in the dental gyrus of hippocampus in response to physical exercise. It is not known whether mitochondrial dysfunction in the hippocampus is responsible for decline in cognitive function associated with low fitness level and aging, and whether intrinsic aerobic capacity is a risk factor for it. Methods: Mitochondrial function was investigated in the hippocampi of young and old highcapacity runner (HCR) and low-capacity runner (LCR) rats using high-performance res…